TAG Chemistry Component Functions and Benefits

TAG-1™  has multiple patents issued and pending. It is a Class 1 general reagent pursuant to 21 CFR 864.4010.

TAG-1 is substantially equivalent to formalin.  Tissue should be stabilized at least 6 hours.

Tissue can then be processed with the same protocols as used for FFPE.

TAG-NGPM+™  and TAG-NGPM™  are based on the TAG-1 chemistry and have additional patents pending

1.  Chaotrope

Degrades nucleases and endonucleases

2.  Chelator

Inactivates Ca and Mg driven enzyme systems – decreasing destruction of cellular contents

3.  Penetrant & metabolic modulator

Drives TAG-1 into tissue and modifies apoptotic cytokines function – slowing cell death

4.  1st Kosmotrope

Maintains cellular integrity and surface antigenic structures by water distribution and metabolism of intracellular and extracellular tissue

5.  Buffer

Slows cell death and deformation by maintaining pH and slowing cell lytic activity and release of cell contents into tissue

6.  2nd Kosmotrope

Maintains integrity of proteins and antigenic structures

7.   Apoptosis substrate

Maintains cellular apoptotic transition and regulatory control cytokines

8.  Mixing formulation

Optimizes components for genetic expression of tissue sample